Activation of TLR-4 receptors by Par-4 in neuronal degeneration in Alzheimer's disease

receptor activation. Moreover, autophagy and lysosomal pathway seem to be involved in As effects. Preincubation of cells with microalgae oil protected retinal cells from As cytotoxicity. Conclusions: P2X7 cell death receptor seems to be an interesting therapeutic target for beta-amyloid-induced degenerative diseases. Docosahexanoic acid modulates P2X7 receptor activation. So, associated to others P2X7 inhibitor, DHA has interesting biological properties which open new perspectives in therapeutics applications.