Research Progress of Novel Anticoagulants

The current anticoagulants available to clinicians such as heparin,warfarin and recombinant hirudins(i.e.bivalirudin,desirudin,lepirudin) have some drawbacks including heparin-induced bleeding,need of laboratory monitoring of warfarin and short half-life of hirudin in vivo.Novel parenteral anticoagulants in development representative by pegmusirudin,HD1-22,flovagatran,otamixaban,RB-006,EP217609 overcome the shortcoming of anticoagulants available now.They provide more alternatives to anticoag-ulant therapy and thrombolytic therapy.The review addresses the advance of novel anticoagulants in development.