Flavonoids from the leaves and stems of Dodonaea polyandra: a Northern Kaanju medicinal plant.

Abstract Three prenylated flavonoids 5,7,4′-trihydroxy-3′(3-methylbut-2-enyl)-3-methoxy flavone, 5,7-dihydroxy-3′(3-methylbut-2-enyl)-3,4′-dimethoxy flavone and 5,7,4′-trihydroxy-3′,5′(3-methylbuyt-2-enyl)-3-methoxy flavone together with three other known flavonoids were isolated from the medicinal plant Dodonaea polyandra . The plant is used in the traditional medicine system of Northern Kaanju people of Cape York Peninsula, Queensland, Australia. The extracts studied have previously been found to possess anti-inflammatory activity. Successive fractionation of leaf and stem extracts by column and high performance liquid chromatography led to the isolation of these compounds. Their structures were determined using a number of spectroscopic techniques including 1D and 2D NMR and high resolution mass spectroscopy. The structural elucidation is reported herein accompanied by full 1 H and 13 C NMR spectroscopic data. Spectroscopic data of known compounds was in agreement with that previously reported in literature.