Dieta a metabolity mikrobioty jelitowej i ryzyko sercowo-naczyniowe wśród pacjentów z przewlekłą chorobą nerek

Patients with chronic kidney disease (CKD) present a higher mortality rate in comparison to the general population. Cardiovascular complications are the main cause of death. Huge interest in the topic of intestinal microbiota causes that there are more and more studies indicating the influence of microorganisms and their metabolites on cardiovascular risk. The metabolites derived from intestinal microbiota are classified as uremic toxins. The best known metabolites are trimethylamine N-oxide, p-cresol sulfate and indoxyl sulfate. The aforementioned uremic toxins promote the development of atherosclerosis and contribute to the chronic inflammation. One of the factors influencing the composition of the gut microbiota is diet. The aim of the study is to present the latest research on metabolites of intestinal microbiota, diet and increased cardiovascular risk among patients with CKD.