Pharmacology of a human dopamine D4 receptor expressed in HEK293 cells.

Dopamine receptors play an important role in neurotransmission within the central nervous system, as evidenced by their affinity to an apparent site of action of a variety of psychotropic agents. The cloning of dopamine receptor subtypes makes possible the discovery of subtype-selective agonist and antagonist compounds useful for the study of receptor physiology and for the developement of more effective treatments for disturbances stemming from aberrant dopamine neurotransmission. We describe in this report the receptor pharmacology of a human D 4 -dopamine receptor expressed in HEK293 cells from a synthetic gene