Clinical Trial of Nanoencapsulated Centella asiatica and Zingiber officinale to Improve Cellulite and Subcutaneous Adipolysis

Objective: The purpose of this study was to determine the effect of nanoencapsulated Centella asiatica and Zingiber officinale extract, with the dose of 3000 mg/day, in reducing cellulite and improving the composition of subcutaneous adipose. Methods: This study used the quasi-experimental with pre and post-controlled design using 38 female subjects who suffer cellulite and have BMI > 25, and met the inclusion and exclusion criteria. Subjects were grouped randomly into the 28-day treatment group, the 42-day treatment group, and control group. Subjects in the treatment groups received the tested herbal with 3000 mg/day (2 x 3 capsules @500 mg) that should be taken in determined duration. Appearance of cellulite and lipid profile were observed and body composition analysis was performed before and after treatment. Data were analyzed using T-test, Wilcoxon or Mann-Whitney, while the comparison of the three treatment groups was tested with ANOVA with 95% confidence level (p Results: The administration of the drug for 28 days can significantly repair the cellulite grade. There was a significant improvement in cholesterol/HDL ratio, which showed that the 28-day treatment group was better than the 42-day treatment group. Compared to control group, the 28-day and the 42-day treatment groups showed better clinical improvements in total cholesterol, LDL, the ratio of LDL/HDL, fasting blood sugar, weight, BMI, body fat, body fat percentage, left and right arm fat, trunk fat, left thigh fat, and cellulite grade. Conclusion: Nanoencapsulated extract of C. asiatica and Z. officinale can improve cellulite, lipid profile, and subcutaneous fat. Key words: Centella asiatica, Zingiber officinale , Cellulite, Subcutaneous fat.