Coenzyme Q10(CoQ10) reduce the heart toxicity caused by anthracycline-based chemotherapy drugs

2012 
Objective:To study the protective effect of CoQ10 on the cardiovascular toxicity induced by anthracycline,and investigate the possible mechanisms.Methods:Sixty tumor patients were randomly divided into treatment group(30 cases) and control group(30 cases).Receiving chemotherapy,at the same time,CoQ10 and a large dose of vitamin E were given in two groups.Electrocardiography and cardiac enzymes were examined before and after treatment.Results: ECG and myocardial enzyme were all improved significantly in the treatment group,and the changes were superior to those of the control group(P0 05).Conclusion:CoQ10 had protective effects on the cardiovascular toxicity induced by anthracycline.
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