Isocyanide-Based MCRs: Straightforward Access to Perfluroalkyl­ated γ-Spiroiminolactones

A variety of perfluoroalkyl-substituted γ-spiroiminolactones have been synthesized via a one-pot, three-component cascade reaction in which isocyanides, methyl perfluoroalk-2-ynoates and 1,2-diketones undergo highly regioselective Michael addition, nucleophilic addition and cyclization. This reaction has the advantages of good to excellent chemical yields, operationally simple procedure, and short reaction times.