Clinical trial of a natural and bioactive melon SuperOxide Dismutase (SOD B Dimpless®) on cellulite

A randomized, double blind, placebo controlled clinical study was conducted on 41 women with cellulite aged between 31 and 50 years old. 21 of these were orally supplemented with SOD B Dimpless®, a natural dry melon juice highly concentrated in SuperOxide Dismutase (SOD) at 40 mg per day (480 IU SOD), during 56 consecutive days. Cellulite was measured visually by scoring fat nodes on stomach and thighs, according to a linear scale. The oral supplementation with SOD B Dimpless® significantly reduced cellulite on thighs compared to the placebo after 28 days. This reduction is amplified after 56 days of supplementation. The mechanism of action may involve the induction of endogenous antioxidant enzymes expression, leading to the inhibition of fibrosis and the stimulation of lipolysis. Further investigations are necessary to document the way of action of SOD B Dimpless® against cellulite.