Hematuria in a Former Smoker

A 75-year-old woman presented with painless, massive hematuria. She was a former smoker but had no history of a bleeding disorder. Laboratory studies revealed a hemoglobin level of 6.7 g/dL [reference interval (RI) 11.2–15.7], prothrombin time (PT)2 of 47.9 s (RI 12.5–15.5), activated partial thromboplastin time (aPTT) of >160 s (RI 25–35), and a thrombin time of …