ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics.

Georgia Levidou,Angelica A. Saetta,Fanie Gigelou,Maria Karlou,Polyanthi Papanastasiou,Angeliki Stamatelli,Nikolaos Kavantzas,Nikolaos V. Michalopoulos,George Agrogiannis,Efstratios Patsouris,Penelope Korkolopoulou

ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics.

2012

Georgia Levidou
Angelica A. Saetta
Fanie Gigelou
Maria Karlou
Polyanthi Papanastasiou
Angeliki Stamatelli
Nikolaos Kavantzas
Nikolaos V. Michalopoulos
George Agrogiannis
Efstratios Patsouris
Penelope Korkolopoulou

Background Colorectal (CRC) carcinogenesis through various morphological stages has been linked to several genetic and epigenetic changes. The Raf/MEK/ERK (MAPK) signal transduction cascade is an important mediator of a number of cellular fates.

Keywords:

DNA-binding protein
Proto-Oncogene Proteins B-raf
MAPK/ERK pathway
Pathology
Signal transduction
Carcinogenesis
Epigenetics
Mutation
Biology
Adenocarcinoma
Exon
Colorectal cancer
Mitogen-activated protein kinase

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