Co-condensation sol-gel temperature controlled

A method of manufacturing macromolecules silica co-condensed releasing NO, comprising: forming a reaction mixture by combining at least one reactant and at least one reagent at a first temperature at which at least one reactant is substantially unreactive in the presence of at least one reagent; and raising the temperature of the reaction mixture to a second temperature at which the at least one reactant is reactive in the presence of at least one reagent; raising the temperature of the reaction mixture to a third temperature which is not lower than the second temperature is less than 40 ° C, which increased the reaction temperature of the reaction mixture to a third temperature comprises increasing the second temperature at the third temperature at a rate of less than 10 ° c per minute, wherein the reaction of at least one reactant in the presence of at least one reagent does not produce macromolecules silica-co-condensed releasing nO.