Intraoperative detection of intimal lipid in the radial artery predicts degree of postoperative spasm
2009
Abstract Background The radial artery's (RA) tendency to spasm when used as a bypass graft may relate to features of the RA itself. We imaged RA conduits before and after CABG in order to characterize intimal abnormalities that might relate to the risk of spasm. Methods RA conduits from thirty-two CABG patients were imaged intraoperatively using catheter-based optical coherence tomography (OCT) and again on day 5 using 64-channel MDCT angiography. The change in luminal diameter between timepoints was measured in the proximal, mid and distal RA. “Spasm” was defined as focal or diffuse luminal narrowing to a diameter less than the target coronary. Lipid content in the RA was quantified by the degree of light attenuation on the OCT image. Results Postoperative spasm was diagnosed in 18 of 32 (56%) RA grafts with the distal RA showing the most severe change versus the mid and proximal portions (−24.1 ± 43.2% vs. −15.3 ± 40.7%, −9.0 ± 42.5% change in diameter respectively, p R = 0.64, p = 0.0005) and was significantly more pronounced in grafts with spasm versus no spasm (−1.97 ± 0.61 mm −1 vs. −0.81 ± 0.57 mm −1 , p Conclusions RA conduits otherwise considered acceptable for bypass grafting were often found by OCT imaging to have a substantial amount of lipid, which in turn strongly relates to the risk of postoperative spasm. Screening conduits based on characteristics of intimal quality may improve results following RA grafting.
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