Parvalbumin Expression in Rat SubventricularZone as Affected by Acute Hypoxia during Early Postnatal Ontogeny
2020
This study aimed to reveal parvalbumin (PVA) expression in
cells of the subventricular zone (SVZ), identify the morphological
type of these cells, and estimate the effect of acute hypoxia on the
size of this cell population in the Wistar rat neonatal period.
PVA-expressing cells were revealed immunohistochemically using Abcam
rabbit polyclonal antibodies to this calcium-binding protein. Rats
were exposed to hypoxia in a special chamber with 7.8% oxygen in
a breathing gas mixture. The brain was examined in the neonatal
period on postnatal days 5 and 10. It was found that the SVZ, both
in control and experimental rats, contains PVA- expressing cells
of the same morphological type, which represent migrating immature
neuroblasts (type A). In control animals, throughout the entire
neonatal period, the number of these cells remains constant and
accounts for more than 20% of the total cell population. Perinatal
hypoxic exposure leads to increase the number of PVA-expressing
cells, as well as the total number of cells, in the SVZ (to 33%).
Thus, perinatal hypoxia activates neurogenesis in the SVZ during
the neonatal period. In the same period, some neuroblasts express
PVA and may reach a certain degree of differentiation of their neurotransmitter
phenotype.
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