Synthesis and insecticidal evaluation of novel anthranilic diamides containing N-substitued nitrophenylpyrazole.

Abstract To cope with developing pest resistance and ecological problems associated with conventional insecticides and to search for potent insecticides targeting at ryanodine receptor (RyR), a series of novel anthranilic diamides containing N-substitued nitrophenylpyrazole were designed and synthesized. The insecticidal activities of target compounds against oriental armyworm ( Mythimna separata ) and diamondback moth ( Plutella xylostella ) were evaluated in our greenhouse by bio-assay tests and the relative structure–activity relationships were briefly discussed. Most compounds exhibited moderate to high activities, in which G 7 and K 5 showed high activity against oriental armyworm and K 2 and K 4 against diamondback moth even better than the control-chlorantraniliprole. The calcium imaging technique was used to investigate the effects of several typical title compounds on the [Ca 2+ ] i , especially the effects of G 7 on the intracellular calcium ion concentration ([Ca 2+ ] i ) in neurons, which indicated that some title compounds were potent activators of the RyR.