Clinical significance of joint detection of procalcitonin and interleukin-6 in the pathogen diagnosis of infectious disease

Objective To study the changes of serum procalcitonin (PCT) and interleukin-6 (IL-6) in the clinical value in the pathogen diagnosis of infectious disease.Methods Using the Up-converting Phosphor Technology based Lateral Flow assay (UPT) to detect 79 cases of bacterial infections,59 cases of viral infectious diseases and 68 cases of healthy normal human serum PCT,IL-6 content,and using receiver operating characteristic(ROC) curve to analyse.Results Bacterial infection group PCT and IL-6 were significantly higher than that of virus group and normal control group,there was significant difference (P ＜0.05),PCT and IL-6 in virus group and normal control group virus infection were not significantly different (P ＞ 0.05) ; application analysis of ROC curves of PCT and IL-6 in diagnosis and differential diagnosis of bacterial infection efficiency,the area under the curve were 0.854 and 0.783,PCT was more effective than IL-6 ; PCT and IL-6 in the detection of bacterial infection,a linear correlation (r =0.424 P ＜ 0.001) ; single PCT detection,the sensitivity and specificity were 82.3％ and 79.5％,the sensitivity and specificity of IL-6 were 69.6％ and 68.5％,the combination of the two detection sensitivity and specificity were 91.1％ and 67％.Conclusion In the diagnosis of pathogen infection,PCT is a good index,if combined with IL-6 detection,differential diagnosis is more conducive to bacteria,virus infection disease. Key words: Calcitonin;  Interleukin-6 ;  Infections/diagnosis