Non-islet cell tumor-induced hypoglycemia due to overproduction of insulin-like growth factor-II--two case reports and literature review

2例非胰岛细胞肿瘤性低血糖(NICTH)患者血清中胰岛素样生长因子(IGF)-Ⅱ水平增高,IGF-Ⅰ、IGF结合蛋白(BP)-3、GH水平受到抑制,IGF-Ⅱ/IGF-Ⅰ异常增高,其中1例间质来源的肿瘤患者术后循环GH-IGF轴恢复至正常范围,表明循环GH-IGF轴改变在NICTH的定性诊断中具有重要价值,IGF-Ⅱ/IGF-Ⅰ是敏感性较高的参数。