Computational modeling of degradation process of biodegradable magnesium biomaterials.
2021
Despite the advantages of using biodegradable metals in implant design, their uncontrolled degradation and release remain a challenge in practical applications. A validated computational model of the degradation process can facilitate the tuning of implant biodegradation by changing design properties. In this study, a physicochemical model was developed by deriving a mathematical description of the chemistry of magnesium biodegradation and implementing it in a 3D computational model. The model parameters were calibrated using the experimental data of hydrogen evolution by performing a Bayesian optimization routine. The model was validated by comparing the predicted change of pH in saline and buffered solutions with the experimentally obtained values from corrosion tests, showing maximum 5% of difference, demonstrating the model's validity to be used for practical cases.
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