TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis

// Ming-Jie Wang 1, * , Hao-Yu Yang 1, * , Hui Zhang 1 , Xindie Zhou 1 , Rui-Ping Liu 1 , Yuan-Yuan Mi 2 1 Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People’s Hospital, Changzhou, China 2 Department of Urology, The Third Affiliated Hospital of Nantong University, Wuxi, PR China * These authors have contributed equally to this work Correspondence to: Rui-Ping Liu, email: liuruiping216@sina.com Yuan-yuan Mi, email: myywxsy2016@sina.com Keywords: TNFAIP3, rheumatoid arthritis, meta-analysis, single nucleotide polymorphism Received: August 08, 2016     Accepted: September 23, 2016     Published: October 13, 2016 ABSTRACT Accumulating evidences suggested that tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs10499194, rs13207033 polymorphisms may be associated with the risk of rheumatoid arthritis (RA). However, these studies yielded contradictory findings. To clarify convincing associations, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, and the China Knowledge Resource Integrated Database. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 13 case-control studies for rs10499194 polymorphism and 6 studies for rs13207033 polymorphism were included. Our data indicated that TNFAIP3 gene rs10499194, rs13207033 polymorphisms were associated with the decreased risk of RA. Stratification analyses of ethnicity indicated rs10499194, rs13207033 polymorphisms decreased the risk of RA among Caucasian populations, but not among Asian populations. In conclusion, this meta-analysis indicates that TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of RA, especially among Caucasian populations.