Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State

Adi Layani-Bazar,Itai Skornick,Alain Berrebi,Maor H. Pauker,Elad Noy,Alon Silberman,Michael Albeck,Dan L. Longo,Yona Kalechman,Benjamin Sredni

Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State

2014

Adi Layani-Bazar
Itai Skornick
Alain Berrebi
Maor H. Pauker
Elad Noy
Alon Silberman
Michael Albeck
Dan L. Longo
Yona Kalechman
Benjamin Sredni

These findings offer a rationale to reposition an experimental drug in human trials to reverse an integrin-mediated mechanism of chemoresistance in acute myeloid leukemia, with immediate translational implications for clinical evaluation in patients.

Keywords:

Drug resistance
Drug
Myeloid leukemia
Experimental drug
Immunology
VLA-4
Medicine
Pharmacology
clinical evaluation
redox modulation
in patient

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