New cytotoxic sulfated saponins from the starfishCertonardoa semiregularis

Two new sulfated saponins designated as certonardosides P2 and l3 (1 and2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfishCertonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds1 and2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.