Suppression of retinal neovascularization by Anti-VEGF monoclonal antibody

Objective:To evaluate the effect of suppression of ischemia-induced retinal neovascularization in vivo by inhibition of vascular endothelial growth factor(VEGF). Method:Murine models of hyperoxia-induced ischemic retinopathy were established. Intravitreal injections were performed with anti-VEGF monoclonal antibody or NS. The nuclei of new vessel buds extending from the retina into the vitreous in different groups are counted and compared. Results:There were plenty of new vessel buds in the eyes of mice in hyperoxia condition. Retinal neovascularization in the eye injected with large-dosage anti-VEGF monoclonal antibody was reduced 54.61% compared with that of the hyperoxia control group(P0.01). Conclusion:The retinal neovascularization were suppressed by using anti-VEGF monoclonal antibody.