Remodelling compartment in root cementum

Bone remodelling represents the most remarkable bone response to mechanical stress and mineral homeostasis. It is the consequence of complex highly orchestrated and tightly regulated cellular processes taking place in a specialized entity - the Bone Remodelling Compartment (BRC). Cementum is an understudied tissues that requires more research to understand its biology, pathology, and potential for regeneration. Although analogue to bone in structure and composition distinct structural and functional differences were ascribed to each of these mineralized tissues. The precise role of cementocytes in cementum turnover is unclear but they may work the same way as osteocytes in bone remodelling, regulating the full process. Although cementum is not liable to regular physiological remodelling as bone is, pathological cases triggered by orthodontic forces or large periapical periodontitis, those lesions can acutely induce cementum remodelling. Nevertheless, the cellular mechanisms behind this particular remodelling process are yet to be identified, as its eventual involvement of specialized anatomic structures as the BRC. Hypothesizing that similar cellular mechanisms underlie bone and cementum remodelling, the present work shows, for the first time, the histological evidence of a specialized remodelling compartment in dental hard tissues.