METABOLIC PRODUCTS FROM SPICARIA DIVARICATA NRRL 5771

Two metabolites, SC-28762 and SC-28763, were produced by Spicaria ditaricata NRRL 5771. The production, the isolation and purification, and the physicochemical properties of the metabolites are described. SC-28762 is 3, 3'-di-(methoxycarbonylmethyl)-3, 3', 4, 4'-tetrahydro-9, 9', 10, 10'-tetrahydroxy-7, 7'-dimethoxy-1, 1'-dioxo-8, 8'-bi-1Hnaphtho[2, 3-c]pyran (viriditoxin). SC-28763 is 3-(2-oxopropyl), 3'-methoxycarbonyimethyl-3, 3', 4, 4'-tetrahydro-9, 9', 10, 10', -tetrahydroxy-7, 7'-dimethoxy-1, 1'-dioxo-8, 8'-bi-IHnaphtho[2, 3-c]pyran. SC-28763 exhibits good antimicrobial activities against anaerobic microorganisms.