A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices

Shiyi Zhang,Andrew M. Bellinger,Dean L. Glettig,Ross Barman,Young-Ah Lucy Lee,Jiahua Zhu,Cody Cleveland,Veronica A. Montgomery,Li Gu,Landon D. Nash,Duncan J. Maitland,Robert Langer,Giovanni Traverso

A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices

2015

Shiyi Zhang
Andrew M. Bellinger
Dean L. Glettig
Ross Barman
Young-Ah Lucy Lee
Jiahua Zhu
Cody Cleveland
Veronica A. Montgomery
Li Gu
Landon D. Nash
Duncan J. Maitland
Robert Langer
Giovanni Traverso

A supramolecular elastic polymer that is stable in the acidic environment of the stomach but dissolves in the neutral-pH environment of the intestines is shown to function as a safe gastric-retentive device in pigs.

Keywords:

Nanotechnology
Supramolecular polymers
Materials science
Polymer
Elastomer
Supramolecular chemistry
Gastrointestinal transit
safety profile
large animal
nutritional modulation
Dosage form

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