CHI3L1 is correlated with childhood asthma.

OBJECTIVE: The aim of this study was to assess the association between CHI3L1 gene two single nucleotide polymorphisms (SNPs) (rs12141494 and rs4950928) and susceptibility to pediatric asthma in a Chinese Han population. METHODS: The case-control study was carried out on 115 children with asthma and 108 healthy controls. Genotypes of rs12141494 and rs4950928 within CHI3L1 gene were determined with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. Chi-square test was employed to analyze the differences of genotype and allele frequencies of the two polymorphisms between case and control groups. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to explain relative susceptibility of pediatric asthma. RESULTS: The frequencies of genotypes and alleles of rs4950928 in CHI3L1 gene showed a significant difference between asthmatic children and healthy controls (P 0.05). CONCLUSION: Our results suggested that rs4950928 in CHI3L1 gene was associated with pediatric asthma risk in a Chinese Han population, while rs12141494 was not.