Role of HSP70 in hepatic ischemia-reperfusion injury:recent progress

Hepatic ischemia-reperfusion(IR) injury is a major cause of liver damage,and has become a hot and difficult field of study.Recent investigations reveal that heat shock protein 70(HSP70) plays a critical role in protection of tissues and organs against IR injury.This paper overviews the actions of HSP70 in liver IR injury,which puts a special emphasis on the mechanisms underlying its protective effect such as regulation of inflammation factors,and anti-apoptotic and antioxidative effect.