Triphenyltin derivatives of sulfanylcarboxylic esters
2018
Abstract The reaction of 3-(aryl)-2-sulfanylpropenoic acids [H 2 x spa; x : p = 3-phenyl-, f = 3-(2-furyl)-, t = 3-(2-thienyl)-] with methanol or ethanol gave the corresponding methyl (H x spme) or ethyl (H x spee) esters. The reaction of these esters (HL) with triphenyltin(IV) hydroxide gave compounds of the type [SnPh 3 L], which were isolated and characterized as solids by elemental analysis, IR spectroscopy and mass spectrometry and in solution by multinuclear ( 1 H, 13 C and 119 Sn) NMR spectroscopy. The structures of [SnPh 3 (pspme)], [SnPh 3 (fspme)] and [SnPh 3 (fspee)] were determined by X-ray diffractometry and the antimicrobial activity against E. coli , S. aureus , B. subtilis , P. aeruginosa , Resistant P. aeruginosa (a strain resistant to ‘carbapenem’), and C. albicans was tested and the in vitro cytotoxic activity against the HeLa-229, A2780 and A2780 cis cell lines was determined for all compounds.
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