The Relation Between Hypercoagulable State and Pulmonary Function in Patients with Cor Pulmonale During Exacerbation Period

Objective: To investigate the relation between hypercoagulable state and pulmonary function in the patients with cor pulmonale during exacerbation period,and study whether to improve the patients pulmonary function by correcting the hypercoagulable state of cor pulmonale besides routine treatment.Method: 78 cases patients with cor pulmonale in exacerbation period were randomly divided into clopidogrel and low molecular heparin group(39 cases) and control group(39 cases).The forced expiratory volume in 1st(FEV1%) and the plasma coagulation parameters of prothrombin time(PT),partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(Fb) were determined in 2 groups before and after treatment.32 cases healthy human subjects proceed comparison with clopidogrel and low molecular heparin group and control group.Result: ①Before the treatment,the levels of Fb was significantly increased(P0.01),and the levels of FEV1 PT,APTT and TT were significantly decreased(P 0.05) in clopidogrel and low molecular heparin group and control group in exacerbation period compared with healthy subjects,but in clopidogrel and low molecular heparin group and control group showed no difference(P 0.05).②After the treatment,in clopidogrel and low molecular heparin group the levels of Fb was significantly decreased(P 0.01),and the levels of FEV1,PT,APTT and TT were significantly increased(P 0.05).③The difference before and after treatment were no significant difference in control group,except for FEV1%(P0.05).④Compared with those of control group after treatment,the level of PT,APTT in clopidogrel and low molecular heparin group were longer and the level of Fb and FEV1% increased(P0.05).Conclusion: ①The patients of cor pulmonale in exacerbation period could cause hypercoagulable state and decrease pulmonary function.②Besides routine treatment,given anti-coagulation,decrease of blood viscosity and the level of fibrinogen therapy could correct the hypercoagulable state of cor pulmonale in erbation period,and improve the patients pulmonary function.