Copper-Catalyzed Oxidative Benzylic C(sp3)–H Amination. Direct Synthesis of Benzylic Carbamates.

A new efficient strategy to access benzylic carbamates through C-H activation is reported. The use of a catalytic amount of Cu(I)/diimine ligand in combination with NFSI ((PhSO2)2NF) or F-TEDA-PF6 as oxidants and H2NCO2R as an amine source, direct leads to the C-N bond formation at benzylic position. The mild reaction conditions, and broad substrate scope make this transformation a useful method for a late-stage incorporation of the ubiquitous carbamate fragment onto hydrocarbons