Effects of cisapride on symptoms of digestive and gastrointestinal hormones in chronic renal failure patients

Objective To study the effects of cisapride on symptoms of digestive and gastrointestinal hormones in chronic renal failure patients. Methods There were 46 cases of chronic renal failure patients in this paper, all patients were given routine treatment of the underlying disease and were randomly divided into two groups. 23 patients were additionally treated with cisapride as research group, and the others as control group. The gastrointestinal symptoms, serum somatostatin (SS), motilin (MOT) and vasoactive intestinal peptide (VIP) and other gastrointestinal hormones and renal function in two groups of patients were compared before and after treatment. Results The score of acid reflux, nausea, vomiting, abdominal distension, belching and other symptoms of hard feces and other gastrointestinal after treatment were significantly lower than that before treatment in research group and after treatment in control group (all P 0.05), and MOT in control group (P>0.05), but the MOT in research group was decreased significantly(P 0.05). Conclusion Conventional treatment combined with cisapride can improve the effect of gastrointestinal symptoms in patients with chronic renal failure, while reducing serum motilin level. Key words: Cisapride; Kidney failure, chronic; Gastrointestinal hormones; Gastrointestinal symptoms