Preparation optimization and in vitro release of baicalin thermosensitive gel

Objective To prepare the thermosensitive in situ gel of baicalin and investigate the in vitro drug release behavior of baicalin.Methods The thermosensitive in situ gel was prepared with baicalin as main component,Poloxamer 407 and Poloxamer 188 as the gel matrixes,together with methyl cellulose as thickening agent.The effects of baicalin dosages,gel matrix ratios,and viscosity regulator on gelatinization temperature were investigated and the in vitro drug release was determined by UV.Results The gelatination temperature for thermosensitive in situ gel of baicalin was 35.3 ℃.Thein vitro accumulate release ratio of baicalin in the thermosensitive gels was 78.06% after 120 min.Conclusion The preparation of baicalin into thermosensitive in situ gel could accelerate drug dissolution rate.Thermosensitive gel of baicalin with qualified characteristics could be preparaed through regulating the baicalin dosage,gel matrix ratios,and viscosity regulator.