A COMPARATIVE STUDY OF INTRAVAGINAL MISOPROSTOL WITH INTRACERVICAL DINOPROSTONE GEL FOR INDUCTION OF LABOR AT TERM

AIM & OBJECTIVE: Labor is the final consequence of pregnancy and is an inevitable event. The aim of this study is to compare efficacy and safety of low dose vaginal misoprostol with dinoprostone gel for induction of labor at term. METHODS: The study was conducted at AVBRH, DMIMS on 262 pregnant women with term pregnancy after application of inclusion and exclusion criteria. The study was divided into two groups on the basis of induction drug given to the patient. Group A received Misoprostol 25μg at every 6 hours to a maximum of five doses; while Group B received 0.5mg dinoprostone gel every six hourly for a maximum of three doses. Outcome such as mode of delivery and induction delivery interval; side effects of drug were assessed in both the groups. RESULT: There was no significant difference in the mode of delivery between the groups. Incidence of Vaginal delivery, LSCS and instrumental delivery were similar in both the groups (70.23% & 67.18%, 22.90% & 26.72%, 6.87% & 6.11%). The mean induction delivery interval is less in misoprostol group (13.83±5.41 hours & 18.29±6.17, p-0.0001).  Requirement of oxytocin augmentation was less in Misoprostol group (44.27% & 72.52% in group A & B respectively). No significant difference was observed in indication of caesarean section and side effects in both the groups (p-0.23, 0.16) CONCLUSION: Low dose vaginal Misoprostol is as efficacious thanDinoprostone gel for induction of labor at term.