Interrelations of changes in liver tissue and chemical composition of the bile and biliary calculi

The correlation between the degree of morphological alterations of the hepatic tissues, changes in the chemical composition of bile and bile stone structure was established after comparing clinico-laboratory findings, results of examinations of liver bioptates, chemical composition of the bile and bile stones in 216 patients with cholelithiasis. The formation of cholesterol and mixed stones in the gallbladder is in correspondence with mild alterations of the liver tissue and colloid stability of the hepatic bile. The formation of pigment stones in the gallbladder and common bile duct is considered to be a symptom of chronic hepatitis followed by deep alterations of the chemical structure of hepatic bile.