TENOFOVIR INDUCED STEVENS-JOHNSON SYNDROME IN A PATIENT WITH ACUTE HEPATITIS B: A RARE CASE REPORT

ABSTRACT Objective To report a rare case of a hepatitis B patient who developed Stevens-Johnson syndrome (SJS) secondary to tenofovir use. Case Summary A 61-year-old female presented with complaints of jaundice, difficulty in swallowing, and burning sensation all over the body along with erythematous polymorphic rash on the face, upper limbs, and trunk. She was diagnosed with SJS secondary to tenofovir. The causality of adverse drug reaction (ADR) was assessed using the WHO-UMC causality scale, and ADR was found to be probable. Tenofovir was withdrawn and the patient was conservatively managed. Conclusion Through the observation of this event, we could figure out the association between tenofovir and Stevens-Johnson syndrome. Prompt withdrawal of offending agents, and the initiation of therapy with systemic corticosteroids, and supportive medication were found to be effective.