Dynamic changes of acute hepatitis B serologic and virologic markers

Objective To analyze the dynamic changes of the clinical characteristics and virology of acute hepatitis B and the pathological characteristics and to investigate the clinical features and prognosis of acute hepatitis B.Methods Analysis was performed on the serology and virology of 155 acute hepatitis B patients,and pathological characteristics of 22 acute hepatitis B patients were analyzed,all cases were inpatients admitted from January 2012 to August 2013 in Beijing Ditan Hospital affiliated to Capital Medical University.Results The male∶ female ratio was 1.87∶ 1,most of the patients were 20-49 years of age (81.2％),in 81.9％ of cases the route of transmission was unknown,11.0％ of patients with AHB had the history of sexual contact with hepatitis B patients or carriers,7.1％ AHB have a family history of hepatitis,drug history,dental treatment history or the history of tattoos,none had hepatitis B vaccination history.ALT,AST,TBiL and anti HBc IgM of hospitalized patients were 1531.56 ± 790.764 U/L,698.64 ±499.844 U/L,102.04 ± 70.194 μ,mol/L and 23.70 ± 8.427 S/CO.ALT,AST,TBiL HBsAg,HBeAg andHBV DNA median recovery time respectively were 30 days,30 days,30 days,30 days,7 days and 7 days after disease onset.Conclusion Age of onset of acute hepatitis B at young or middle age,sexual contact may be the most important route of transmission.The prognosis of acute hepatitis B is good,but some cases still progressed into chronic hepatitis.The transaminase and jaundice of most patients returned to normal within two months,HBsAg seroconversion occurred within three months.At 3 months,HBsAg positive patients who received antiviral therapy would have better outcome. Key words: Hepatitis B virus ;  Hepatitis B ;  Clinical features ;  Viral marker