Effects of docetaxel, oxaliplatin and their combination on HeLa strain of cervical cancer

Abstract Objective To study the inhibitory effect of docetaxel (DOC), oxaliplatin (OXA) and their combination on proliferation of cervical cancer line HeLa. Methods Cell morphological changes were observed by inverted phase contrast microscope, cell inhibition rates in different groups were examined by MTT, and cell cycle and apoptosis rates were determined by flow cytometry (FCM). Results DOC and OXA inhibited the proliferation of cervical cancer cell line HeLa in a dose-dependent, and combination of the two drugs had an enhanced inhibitory effect; the apoptosis rate was also significantly increased when the two drugs were used in combination. Conclusion DOC and OXA can synergistically inhibit the proliferation of cervical cancer cell line HeLa, which indicates that combination of the two drugs might has a promising future for clinical treatment of cervical cancer.