Utility of serum IgG, IgG4 and carbonic anhydrase II in distinguishing autoimmune pancreatitis from pancreatic cancer and chronic pancreatitis

s / Pancreatology 13 (2013) S2–S98 S73 Bod , Tam as Moln ar , P eter L egr adi , Judit Czelecz , Attila P alv€ olgyi , Annam aria Szabolcs , Rich ard R oka , Gy€ orgy Gyimesi , R obert Tak acs , Istv an Hritz , DezsT Kelemen , Tam as Forster , Ferenc Izb eki , Gy€ orgy Gy€ orgy , Tibor Tibor , P eter P eter , Tam as Tam as . 1 First Department of Medicine, University of Szeged, Hungary Department of Surgery, University of Szeged, Hungary National Institute of Oncology, Budapest, Hungary 4 Fej er Megyei Szent Gy€ orgy Hospital, Sz ekesfeh erv ar, Hungary Dr. Bugyi Istv~ Ain Hospital, Szentes, Hungary 6 Bethasda Children’sHospital, Budapest, Hungary Department of Surgery, University of P~ A cs, Hungary 8 Second Department of Medicine, University of Szeged, Hungary Introduction: We conducted a survey to clarify the clinical features of chronic pancreatitis (CP) patients in Hungary, based on a multicentric national registry. Aims: Here we demonstratet the initial results. Patients & methods: Data on 84 treated and newly diagnosed CP patients were collected retrospectively. Clinico-pathological information on individual patients including symptoms, etiology, diagnostic criteria, treatment and complications were collected from medical records and questioners completed by the patients. Results: There were 66 male and 18 female patients with a mean SD age of onset of 47.5 11.0 and 45.4 13.0. Patients were classified by alcoholic 53.3% and non-alcoholic 46.4% etiology. Alcoholic CP affected more males than females accounting for 59.0% and 33.3% respectively. Investigation of four major clinical features including abdominal pain, comorbidity with diabetes mellitus (DM), malabsorbtion and pancreatic calcifications revealed that abdominal pain affects more females 61.1% than males 48.5%, DM occurred in 50.0% of males and in 39.8% of females, malabsorbtion affected 19.7% of males and 22.2% of females, and calcifications occurred in 57.6% of males and in 56.3% of females. Calcifications were more common with alcoholic etiology 66.7%, than in non-alcoholic CP 51.4%. 80.0% of patients received enzyme replacement, 28.5% had endoscopic treatment, 11.9% went through pancreatic resection and 27.2% had decompressive surgery. Conclusion: The most common etiology for CP is excessive alcohol consumption, it dominantly affects males and calcificating form is more frequent, especially in alcoholic cases. These correspond to international tendencies observed in CP. The registry provides a foundation for prospective clinical investigations of CP. PII-69 Abstract id: 132. Utility of serum IgG, IgG4 and carbonic anhydrase II in distinguishing autoimmune pancreatitis from pancreatic cancer and chronic pancreatitis Renata Talar-Wojnarowska , Anita Gasiorowska , Marek Olakowski , Pawel Lampe , Magdalena Kujawiak , Janina Grzegorczyk , Ewa Malecka-Panas . Department of Digestive Tract Diseases, Medical University of Lodz, Poland Department of Digestive Tract Surgery, Silesian Medical University, Katowice, Poland Department of Microbiology and Medical Immunology, Medical University of Lodz, Poland Introduction: Autoimmune pancreatitis (AIP) can mimic pancreatic cancer in its clinical presentation, imaging features and laboratory parameters. Aims: In the present study, sera from patients with AIP, pancreatic adenocarcinoma (PA) and chronic pancreatitis (CP) were evaluated for IgG, IgG4 and carbonic anhydrase II (CAII). Patients & methods: The study included 124 patients: 45 with PA, 24 with AIP and 55 with alcoholic CP. The serum levels of IgG, IgG4 and CAII were measured and the associations of the IgG, IgG4, and CAII and clinical data at diagnosis have been evaluated. Results: Serum levels of IgG, IgG4 and CAII were higher in AIP patients compared to PA and CP patients (p Conclusion: Elevated serum IgG4 levels are characteristic in AIP. However, elevations in serum IgG4, even more than 280 mg/dl, may be seen in subjects with PA and cannot be used alone to distinguish AIP from pancreatic cancer. PII-70 Abstract id: 303. The importance of genetic testing in children with idiopathic chronic pancreatitis Eszter Hegyi , Iveta Cierna , Ludmila Vavrov a , Michal Kone cný , L aszl o