Dietary D-psicose in substitution for sucrose influences adipose tissue metabolism in a mouse model of obesity

D-psicose (DP), a C-3 epimer of D-fructose, is known to possess anti-adipogenic effect. We investigated the effect of dietary DP substitution for sucrose on adipose tissue metabolism in ob/ob mice. C57BL/6J ob/ob mice were assigned to either AIN-93G or 5% w/w DP diet. After sacrifice on week 12, we measured adipose tissue mass, adipocyte size, and fat deposition. We determined the mRNA expression of genes related with inflammation and adipogenesis in white adipose tissue (WAT). Gene expression patterns of WAT and pathway analysis were performed using Illumina MouseRef-8 and Ingenuity Pathway Analysis, respectively. In mice fed DP supplemented diet, body weight, mass of adipose tissue, adipocyte size, and fat deposition decreased.The mRNA expression of genes related with inflammation (TNF-α, IL-6) and adipogenesis (PPAR-γ, C/EBP-α) in WAT decreased in mice fed DP supplemented diet. Genomic analysis revealed that 63 up-regulated and 106 down-regulated genes were affected by DP supplemented diet. The top net...