Systems Biology of Polycystic Kidney Disease: a Critical Review

The proliferation and diminishing costs of ‘omics’ approaches have finally opened the doors for small and medium laboratories to enter the ‘systems biology era’. This is a welcome evolution that requires a new framework to design, interpret, and validate studies. Here, we highlight some of the challenges, contributions, and prospects of the ‘cyst-ems biology’ of polycystic kidney disease. WIREs Syst Biol Med 2015, 7:39–52. doi: 10.1002/wsbm.1289 For further resources related to this article, please visit the WIREs website. Conflict of interest: The authors have declared no conflicts of interest for this article.