Paraneoplastic stiff-person syndrome: No tumor progression over 5 years

Stiff-person syndrome (SPS) is a rare disorder characterized by progressive stiffness of predominantly axial and proximal limb muscles, and painful spasms that are often precipitated by startle, emotional, and tactile stimuli.1 Evidence for an autoimmune pathogenesis has been derived from the detection of autoantibodies against glutamic acid decarboxylase in serum and CSF in up to 90% of SPS cases.2,3⇓ In occasional cases, SPS is considered to be of paraneoplastic origin, with amphiphysin being presumably the most common autoantigen.4,5⇓ Three years …