Human IL18-IL2 fusion protein as a potential antitumor reagent by enhancing NK cell cytotoxicity and IFN-γ production

Guangying Du,Liang Ye,Guoying Zhang,Qiuju Dong,Kun Liu,Jingwei Tian

Human IL18-IL2 fusion protein as a potential antitumor reagent by enhancing NK cell cytotoxicity and IFN-γ production

2012

Guangying Du
Liang Ye
Guoying Zhang
Qiuju Dong
Kun Liu
Jingwei Tian

Purpose To obtain a human IL18-IL2 fusion protein by genetic engineering methods and investigate its antitumor activity and mechanism in tumor-bearing mouse models.

Keywords:

NK Cell Cytotoxicity
Reagent
Interleukin 18
Interleukin 2
Lymphokine-activated killer cell
Fusion protein
Immunology
Natural killer cell
Biology
Cell culture
Cytotoxicity

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