Zn((L)-proline) 2 : A Novel and Recyclable Catalyst for the Synthesis of 2-Aryl-4(3H)-quinazolinones in Solvent-Free Conditions

An efficient, solvent-free and facile synthesis of 3-aryl quinazolinones from cyclocondensation of 2-aminobenzamides with aryl aldehydes catalyzed by Zn((L)-proline)2 in the presence of CuCl2 is described. The salient features of the reaction include good yields , mild reaction conditions , low loading of catalyst , and operational simplicity. The catalyst is reusable and can be applied several times without considerable decrease in the yields and rates of the reactions.