Association between visceral adiposity, BMI, and clinical outcomes in postmenopausal women with operable breast cancer.

513 Background: High body mass index (BMI), an indicator of excess body fat, has been shown to negatively impact clinical outcomes in breast cancer. Metabolic dysfunction associated with high visceral fat may be contributory. Since BMI provides no information on the anatomical distribution of stored fat, we conducted this retrospective study to examine the association between visceral adiposity parameters and clinical outcomes. Methods: 1,237 postmenopausal women with stage I-III invasive breast cancer, diagnosed between 1997 to 2012, and who received neoadjuvant chemotherapy (NC) were included. Computed tomography images were used to quantify visceral fat (VFA) and subcutaneous fat area (SFA). The VFA/SFA Ratio was used as a metric of regional fat distribution. We conducted univariate and multivariate analyses to examine the association between body composition parameters (VFA, SFA, VFA/SFA Ratio, BMI) and key outcomes (pathologic complete response [pCR], relapse-free [RFS], disease-specific [DSS] and ov...