Comparative Analysis of Safety, Efficacy and Fetomaternal Outcome of Induction of Labour with Mifepristone versus Intracervical Dinoprostone Gel.

Mifepristone and Dinoprostone used in inducing labour in late pregnancy by acting as cervical ripening drugs. Present study was done to compare and portrait the beneficial effects of both the drugs for induction of labour. The objective was comparative analysis of safety, efficacy and fetomaternal outcome of induction of labour with Mifepristone versus intracervical Dinoprostone gel. 100 patients were included after taking their informed consent. 50 patients were placed in each group A and B. Tablet Mifepristone 200mg orally was given in group A patients and intracervical gel induction was done in group B patients. Pre induction Bishop’s score was noted at beginning to compare improvement in Bishop’s score after induction, mode of delivery and induction-delivery interval in both the groups. Rate of successful IOL or vaginal delivery was 84% with Mifepristone and 56% with Dinoprostone. After induction with Mifepristone 94% women had cervical ripening as compared to 80% with Dinoprostone. 20% Mifepristone treated group required Oxytocin for augmentation as compared to 56% in Dinoprostone. Among the babies, 6% and 14% belonging to Mifepristone and Dinoprostone group respectively, required NICU admissions. In the present study, women who were induced with Mifepristone showed significantly more improvement in Bishop’score than Dinoprostone. Although overall average induction- delivery interval was more in Mifepristone group (29hours) than Dinoprostone group (21hours), vaginal mode of delivery with Mifepristone was more, decreasing the incidence of caesarean section with lesser need for augmentation with Oxytocin. Lesser NICU admissions and maternal complications were noted with Mifepristone. Thus, Mifepristone is a better drug for successful induction of labour as compared to Dinoprostone with a better fetomaternal outcome.