P-0301 Circulating Folate, Vitamine B12, Homocysteine, and Risk of Colorectal Cancer: A Case-Control Study in Tunisian Population

ABSTRACT Introduction Disturbed folate metabolism is associated with an increased risk of some cancers. Our objective was to determinate whether blood levels of folate, Vitamine B12 and homocysteine with colorectal cancer (CRC) risk. Methods Matched case-control study in the Tunisian population (42% men and 58% women) ages 49 to 71 years. Plasma concentration of folate B12 (cobalamin) and total homocysteine were measured in 150 cases and 150 controls. This study estimates for associations of folate, B12 and homocysteine with CRC. Results In this study increased folate concentration showed positive association with colorectal cancer risk [highest versus lowest quartile of folate odds ratio (OR)=1.35 (1.6-2.01) P trend =0.01]. Vitamin B12, homocysteine were not associated with CRC risk. Conclusion Folate is associated with increased CRC risk.