Research progress of aptamer and organic nanomaterials based tumor targeting drug delivery systems

Aptamers are DNA or RNA fragments that can specifically bind to target substances. Because of the excellent properties such as strong binding force, high specificity, small physical size, chemical synthesis and modification, good biocompatibility, and low immunogenicity aptamers show wide application propects in biomedical researches. Aptamers can also bind specifically to receptors on the surface of cell membranes, and mediate the endocytosis of nanoparticles into cells, making them ideal drug targeting ligands. Organic nanomaterials have excellent application value in nanodrug delivery system because of their good biocompatibility and degradability. In this paper, the recent research progress of aptamers and organic nanomaterials drug delivery systems was reviewed. Key words: Aptamers; Organic nanomaterials; Targeting delivery system