Preprocedural Statin Therapy in Percutaneous Coronary Intervention

Objective:To review the published literature regarding the effectiveness or preprocedural statin therapy for the prevention of cardiac events after percutaneous coronary intervention (PCI).Data Sources:Searches of MEDLINE (1966–May 2007) and Cochrane Database (1993–May 2007) were conducted using the search terms statins, HMG-CoA reductase inhibitors, percutaneous coronary intervention, and myocardial necrosis. Limits included articles written in English with human subjects. Additional data were identified through bibliographic reviews.Study Selection and Data Extraction:All English-language articles identified from the data sources were evaluated. Trials and studies were eligible for Inclusion if they evaluated the effectiveness of preprocedural statin therapy for the prevention of cardiac events after PCI.Data Synthesis:Hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) provide benefits relative to morbidity and mortality as primary and secondary prevention of cardiovascular events...