Acute viral necrosis of the liver

: The paper discusses problems of the prevention and treatment of fulminant hepatitis running with massive and submassive hepatic necrosis in evidence of immunodeficiency. The occurrence of most cases is associated with parenteral mode of the infection entry, violation of antiepidemic regulations in hospitals and lack of donors' supervision. High mortality persisting in hospitals requires urgent measures to control parenteral infection with viral hepatitis of different antigenic variants.