The effect of hypothalamic stimulation on the growth transplanted sarcomas

Hypothalamic stimulation repeated many times over a long period in albino rats produced one of two different effects on the growth of grafted 45 and M-1 sarcomas. If the stimulation preceded the transplantation, the growth of the tumor was suppressed, and the tumor might even be completely absorbed. If stimulation followed the transplantation, tumor growth was intensified. A number of hypothalamic nervous structures were involved.